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Article

Role of C/A Polymorphism at −20 on the Expression of Human Angiotensinogen Gene

1 Jan 1999

Abstract excerpt

-Angiotensinogen is the glycoprotein precursor of 1 of the most potent vasoactive hormones, angiotensin II. Human angiotensinogen gene contains a C/A polymorphism at -20 located between the TATA box and transcriptional initiation site. We show here that when nucleoside A is present at -20, this sequence binds to the estrogen receptor. We also show that transcriptional activity of reporter constructs containing...

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Share to Cytokine Signaling Pathways and Interactions
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PMID: 9931090
DOI: 10.1161/01.hyp.33.1.108

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