Lack of correlation between mitotic arrest or apoptosis and antitumor effect of docetaxel.

doi:10.1007/s002800050879

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Article

Lack of correlation between mitotic arrest or apoptosis and antitumor effect of docetaxel.

Cancer chemotherapy and pharmacology - 1 Jan 1999

Schimming R, Mason K A, Hunter N, Weil M, Kishi K, Milas L

Abstract excerpt

PURPOSE: To determine, as we did for paclit-axel, whether mitotic arrest and apoptosis induced in murine tumors in vivo by docetaxel correlate with the drug's antitumor effect and whether the antitumor efficacy of docetaxel depends on p53 mutational status of tumors. METHODS: C3Hf/Kam mice were i...

Topics

Animals
Antineoplastic Agents, Phytogenic
Apoptosis
Docetaxel
Genes, p53
Mice
Mice, Inbred Strains
Mitosis
Mutation
Neoplasms, Experimental
Paclitaxel
Specific Pathogen-Free Organisms
Taxoids

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