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Article

Identification and cloning of a novel cellular protein Naf1, Nef‐associated factor 1, that increases cell surface CD4 expression1

8 Jan 1999

Abstract excerpt

The nef gene of human and simian immunodeficiency virus is a key factor in acquired immunodeficiency syndrome pathogenesis and virus replication. Several Nef-induced phenomena, including the down-regulation of CD4 molecule, have been previously reported. In this study, we have identified and cloned a novel cellular protein Naf1 (Nef-associated factor 1), which associated with Nef in the yeast two-hybrid system...

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PMID: 9923610
DOI: 10.1016/s0014-5793(98)01631-7

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