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Article

Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes

15 Jul 1996

Abstract excerpt

We have identified a new recurrent reciprocal translocation between chromosome 3 and 12 with breakpoints at bands 3q26 and 12p13, t(3;12)(q26;p13) in the malignant cells from five patients with acute transformation of myelodysplastic syndrome or blast crisis of chronic myelogenous leukemia. t(3;12)(q26;p13) appears as a rare but nonrandom event present in various myeloid leukemia subtypes, which is frequently...

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Identifiers

PMID: 8695816
DOI: 10.1182/blood.v88.2.682.bloodjournal882682

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Related research

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Research trail→

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Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromesPMID 8695816Read ↗

Identification of new partner chromosomes involved in fusions with theETV6 (TEL) gene in hematologic malignanciesSemantic proximity Read ↗

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Identification of new translocations involving ETV6 in hematologic malignancies by fluorescence in situ hybridization and spectral karyotypingSemantic proximity Read ↗

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A new translocation, t(2;4;12)(p21;q12;p13), in CD7-positive acute myeloid leukemia: a variant form of t(4;12).Semantic proximity Read ↗

Cytogenetic and molecular characterization of double inversion 3 associated with a cryptic BCR-ABL1 rearrangement and additional genetic changes.Semantic proximity Read ↗

Biallelic ETV6 rearrangements by recurrent translocations t(7;12)(p15;p13) and t(3;12)(q26.2;p13) in acute myeloid leukemia.Semantic proximity Read ↗

Fusion ofTEL/ETV6 to a novelACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)Semantic proximity Read ↗

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid LeukemiaSemantic proximity Read ↗

Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid LeukemiaSemantic proximity Read ↗

Fusion of ETV6 to Neurotrophin-3 Receptor TRKC in Acute Myeloid Leukemia With t(12;15)(p13;q25)Semantic proximity Read ↗

Clinical and genetic studies of ETV6/ABL1‐positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylateSemantic proximity Read ↗

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