Article
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.
Nature genetics - 1 Jan 1999
Jiang X R, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar A G, Wahl G M, Tlsty T D, Chiu C P
Abstract excerpt
Expression of the human telomerase catalytic component, hTERT, in normal human somatic cells can reconstitute telomerase activity and extend their replicative lifespan. We report here that at twice the normal number of population doublings, telomerase-expressing human skin fibroblasts (BJ-hTERT)...
Topics
- Aspartic Acid
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p16
- DNA-Binding Proteins
- Enzyme Inhibitors
- Humans
- Hydroxyurea
- Nucleic Acid Synthesis Inhibitors
- Phenotype
- Phosphonoacetic Acid
- Phosphorylation
- Protein Biosynthesis