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Article

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.

Nature genetics - 1 Jan 1999

Jiang X R, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar A G, Wahl G M, Tlsty T D, Chiu C P

Abstract excerpt

Expression of the human telomerase catalytic component, hTERT, in normal human somatic cells can reconstitute telomerase activity and extend their replicative lifespan. We report here that at twice the normal number of population doublings, telomerase-expressing human skin fibroblasts (BJ-hTERT) and retinal pigment epithelial cells (RPE-hTERT) retain normal growth control in response to serum deprivation, high...

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Identifiers

PMID: 9916802
DOI: 10.1038/5056

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.PMID 9916802Read ↗

Absence of cancer–associated changes in human fibroblasts immortalized with telomeraseSemantic proximity Read ↗

Transformation of normal human cells in the absence of telomerase activationSemantic proximity Read ↗

Lack of cell cycle regulation of telomerase activity in human cellsSemantic proximity Read ↗

Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells.Semantic proximity Read ↗

Lack of telomerase activity in human mesenchymal stem cellsSemantic proximity Read ↗

Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte ImmortalizationSemantic proximity Read ↗

Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT).Semantic proximity Read ↗

Telomerase-immortalized sheep fibroblasts can be reprogrammed by nuclear transfer to undergo early development.Semantic proximity Read ↗

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformationSemantic proximity Read ↗

Resistance to telomerase inhibition by human squamous cell carcinoma cell lines.Semantic proximity Read ↗

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpartSemantic proximity Read ↗

The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylationSemantic proximity Read ↗

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