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Article

Evolution and diversity of the complement system of poikilothermic vertebrates.

Immunological reviews - 1 Dec 1998

Sunyer J O, Lambris J D

Abstract excerpt

In mammals the complement system plays an important role in innate and acquired host defense mechanisms against infection and in various immunoregulatory processes. The complement system is an ancient defense mechanism that is already present in the invertebrate deuterostomes. In these species as well as in agnathans (the most primitive vertebrate species), both the alternative and lectin pathway of complement...

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PMID: 9914901
DOI: 10.1111/j.1600-065x.1998.tb01251.x

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