Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.

Molecular biology and evolution - 1 May 1994

Hughes A L

Abstract excerpt

A phylogenetic analysis of DNA sequences from the C3/C4/C5 complement-component family of vertebrates supported the hypothesis that the C5 gene diverged first from the common ancestor of C3 and C4 and that C3 and C4 diverged later. The close relationship of C3 and C4 was further supported by the...

Topics

Animals
Complement C3
Complement C4
Complement C5
Complement System Proteins
Genetic Variation
Humans
Mice
Multigene Family
Phylogeny

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8015436
DOI: 10.1093/oxfordjournals.molbev.a040123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8015436-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.PMID 8015436Read ↗

Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in FishSemantic proximity Read ↗

The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory ActivitySemantic proximity Read ↗

The complement component C5 of the common carp (Cyprinus carpio): cDNA cloning of two distinct isotypes that differ in a functional site.Semantic proximity Read ↗

Molecular characterization of complement component 3 (C3) in Mytilus coruscus improves our understanding of bivalve complement systemSemantic proximity Read ↗

Genetics of human complement component C4 and evolution the central MHC.Semantic proximity Read ↗

Evolution and diversity of the complement system of poikilothermic vertebrates.Semantic proximity Read ↗

C6-Like and C3-Like Molecules from the Cephalochordate, Amphioxus, Suggest a Cytolytic Complement System in InvertebratesSemantic proximity Read ↗

Expansion of genes encoding complement components in bony fish: biological implications of the complement diversitySemantic proximity Read ↗

Structures of complement component C3 provide insights into the function and evolution of immunitySemantic proximity Read ↗

Complement C3 and its polymorphism: biological and clinical consequences.Semantic proximity Read ↗

Molecular cloning and protein analysis of divergent forms of the complement component C3 from a bony fish, the common carp (Cyprinus carpio): presence of variants lacking the catalytic histidine.Semantic proximity Read ↗

The complete complement of C1q-domain-containing proteins in Homo sapiens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.