Article
Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes.
Circulation - 4 Aug 1998
Wessely R, Henke A, Zell R, Kandolf R, Knowlton K U
Abstract excerpt
BACKGROUND: Enteroviral ribonucleic acids have been identified in heart muscle of a subset of patients with myocarditis and dilated cardiomyopathy as well as in a mouse model of persistent coxsackievirus B3 (CVB3) infection, suggesting that persistent viral infection along with activation of an i...
Topics
- Animals
- Animals, Newborn
- Cardiomyopathies
- Cells, Cultured
- Coxsackievirus Infections
- Cytopathogenic Effect, Viral
- DNA, Complementary
- DNA, Viral
- Enterovirus B, Human
- Gene Expression Regulation, Viral
- Genetic Vectors
- Heart
- Mutation
- Myocardium
- Polymerase Chain Reaction
- RNA, Viral
- Rats
- Rats, Sprague-Dawley