Article
Receptor selectivity of the cloned opossum G protein-coupled receptor kinase 2 (GRK2) in intact opossum kidney cells: role in desensitization of endogenous alpha2C-adrenergic but not serotonin 1B receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1999
Lembo P M, Ghahremani M H, Albert P R
Abstract excerpt
To characterize the specificity of endogenously expressed G protein-coupled receptor kinases (GRKs) for endogenous Gi-coupled alpha2C-adrenergic and serotonin 1B (5-HT1B) receptors in the opossum kidney (OK) cell line, we have isolated a 3.073-kb OK-GRK2 clone encoding a 689-amino acid protein th...
Topics
- Adrenergic alpha-Agonists
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Brimonidine Tartrate
- Cell Line
- Cloning, Molecular
- Colforsin
- Cyclic AMP-Dependent Protein Kinases
- G-Protein-Coupled Receptor Kinase 2
- Kidney
- Molecular Sequence Data
- Mutation
- Opossums
- Quinoxalines
- Rats
- Receptor, Serotonin, 5-HT1B