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Article

Genetic Disorders of Membrane Transport III. Congenital chloride diarrhea.

The American journal of physiology - 1 Jan 1999

Kere J, Lohi H, Höglund P

Abstract excerpt

Congenital chloride diarrhea (CLD) is a recessively inherited disorder of intestinal electrolyte absorption that involves, specifically, Cl-/HCO-3 exchange. CLD is caused by mutations in a chromosome 7 gene, first known as DRA (for downregulated in adenoma). The disease occurs in all parts of the world but is more common in some populations with genetic founder effects. More than 20 mutations in the gene are...

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Identifiers

PMID: 9886972
DOI: 10.1152/ajpgi.1999.276.1.G7

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