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Article

Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone

1 Jan 1999

Abstract excerpt

We examined the effect of PGs, particularly PGF2alpha, on basic fibroblast growth factor-2 (FGF-2) messenger RNA (mRNA) and protein in the rat osteoblastic cell line Py1a and in fetal rat calvariae. Py1a cells expressed multiple FGF-2 mRNA transcripts. PGF2alpha dose-dependently increased the 6-kb transcript at 6 h. The selective PGF2alpha agonist, fluprostenol (Flup), was more potent than PGF2alpha. Phorbol...

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PMID: 9886855
DOI: 10.1210/endo.140.1.6442

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