Article
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse.
The Journal of clinical investigation - 1 Jan 1999
Wang J, Takeuchi T, Tanaka S, Kubo S K, Kayo T, Lu D, Takata K, Koizumi A, Izumi T
Abstract excerpt
The mouse autosomal dominant mutation Mody develops hyperglycemia with notable pancreatic beta-cell dysfunction. This study demonstrates that one of the alleles of the gene for insulin 2 in Mody mice encodes a protein product that substitutes tyrosine for cysteine at the seventh amino acid of the A chain in its mature form. This mutation disrupts a disulfide bond between the A and B chains and can induce a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.