Article
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse.
The Journal of clinical investigation - 1 Jan 1999
Wang J, Takeuchi T, Tanaka S, Kubo S K, Kayo T, Lu D, Takata K, Koizumi A, Izumi T
Abstract excerpt
The mouse autosomal dominant mutation Mody develops hyperglycemia with notable pancreatic beta-cell dysfunction. This study demonstrates that one of the alleles of the gene for insulin 2 in Mody mice encodes a protein product that substitutes tyrosine for cysteine at the seventh amino acid of the...
Topics
- Alleles
- Animals
- Base Sequence
- C-Peptide
- CHO Cells
- Carrier Proteins
- Cricetinae
- Diabetes Mellitus, Type 2
- Endoplasmic Reticulum Chaperone BiP
- Fluorescent Antibody Technique
- Genotype
- Heat-Shock Proteins
- Insulin
- Islets of Langerhans
- Mice