Article
Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens.
International journal of radiation biology - 1 Dec 1998
Mothersill C, Crean M, Lyons M, McSweeney J, Mooney R, O'Reilly J, Seymour C B
Abstract excerpt
PURPOSE: Delayed expression of lethal mutations in the progeny of cells which survived a toxic insult was first shown for ionizing radiation and is one of the signs of induced genomic instability. The effect appears to be related to DNA strand breakage or repair but not to the physical break itse...
Topics
- Antineoplastic Agents
- Apoptosis
- Cell Division
- Cell Line
- Cell Survival
- Clone Cells
- DNA Damage
- Gamma Rays
- Humans
- Keratinocytes
- Mutagens
- Mutation
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Radiation, Ionizing
- Ultraviolet Rays
- bcl-2-Associated X Protein