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Article

A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations.

Protein engineering - 1 Nov 1998

Wallqvist A, Smythers G W, Covell D G

Abstract excerpt

We investigated the HIV-1 protease molecule for the occurrence of cooperative folding units, i.e. structural units that exhibit a relatively stronger protection against unfolding than do other parts of the molecule. Calculated unfolding penalties are used to delineate folding units. This procedure identifies a folding core in HIV-1 protease, based on an ensemble of denatured states derived from native structures,...

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Identifiers

PMID: 9876920
DOI: 10.1093/protein/11.11.999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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