A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations.

doi:10.1093/protein/11.11.999

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Article

A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations.

Protein engineering - 1 Nov 1998

Wallqvist A, Smythers G W, Covell D G

Abstract excerpt

We investigated the HIV-1 protease molecule for the occurrence of cooperative folding units, i.e. structural units that exhibit a relatively stronger protection against unfolding than do other parts of the molecule. Calculated unfolding penalties are used to delineate folding units. This procedur...

Topics

Amino Acid Sequence
Anti-HIV Agents
HIV Protease
HIV Protease Inhibitors
HIV Reverse Transcriptase
HIV-1
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Protein Folding

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