Article
Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice.
Arthritis and rheumatism - 1 Dec 1998
Fleck M, Kern E R, Zhou T, Lang B, Mountz J D
Abstract excerpt
OBJECTIVE: To analyze Fas and tumor necrosis factor receptor I (TNFRI) apoptosis pathways in salivary gland inflammatory disease induced by murine cytomegalovirus (MCMV) infection. METHODS: Four different strains of mice (C57BI/6 [B6]-+/+, Fas-deficient B6-lpr/lpr, TNFRI-deficient B6-tnfr1(0/0),...
Topics
- Animals
- Antibody Formation
- Apoptosis
- Autoantibodies
- Cytomegalovirus Infections
- Female
- Immunophenotyping
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Muromegalovirus
- Mutation
- Receptors, Tumor Necrosis Factor
- Salivary Glands
- Sialadenitis
- Sjogren's Syndrome
- fas Receptor