Article
Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q.
Molecular carcinogenesis - 1 Dec 1998
van der Heijden O, Chiu H C, Park T C, Takahashi H, LiVolsi V A, Risinger J I, Barrett J C, Berchuck A, Evans A C, Behbakht K, Menzin A W, Liu P C, Benjamin I, Morgan M A, King S A, Rubin S C, Boyd J
Abstract excerpt
Uterine leiomyoma is a benign smooth muscle tumor of the myometrium and is the most commonly encountered neoplasm in women of reproductive age. As for most benign tumors, the pathogenesis of leiomyoma remains obscure, especially at the molecular genetic level. The purpose of this study was to per...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 7
- DNA, Neoplasm
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Leiomyoma
- Loss of Heterozygosity
- Microsatellite Repeats
- Uterine Neoplasms