Article
Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer.
Annals of internal medicine - 15 Dec 1998
Furuta T, Ohashi K, Kamata T, Takashima M, Kosuge K, Kawasaki T, Hanai H, Kubota T, Ishizaki T, Kaneko E
Abstract excerpt
BACKGROUND: Omeprazole is metabolized by S-mephenytoin 4'-hydroxylase (CYP2C19) in the liver. In persons with a poor-metabolizer genotype for CYP2C19, the therapeutic efficacy of omeprazole may be increased. OBJECTIVE: To investigate whether CYP2C19 genotype status is associated with cure rates f...
Topics
- Adult
- Amoxicillin
- Anti-Ulcer Agents
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Drug Therapy, Combination
- Female
- Genotype
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Liver
- Male
- Middle Aged