Article
HLA restriction patterns of gliadin- and astrovirus-specific CD4+ T cells isolated in parallel from the small intestine of celiac disease patients.
Tissue antigens - 1 Nov 1998
Molberg O, Lundin K E, Nilsen E M, Scott H, Kett K, Brandtzaeg P, Thorsby E, Sollid L M
Abstract excerpt
Celiac disease is a common HLA-DQ2-associated enteropathy caused by an abnormal T-cell-mediated immune response to ingested wheat gliadin proteins. We have previously isolated in situ activated mucosal T cells from celiac disease patients and demonstrated that these T cells were gliadin specific and predominantly DQ2 restricted. In contrast to this, gliadin-specific T cells isolated from peripheral blood display...
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