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Article

Production of a panel of recombinant gliadins for the characterisation of T cell reactivity in coeliac disease

1 Jan 2000

Abstract excerpt

BACKGROUND/AIMS: Coeliac disease is a chronic intestinal disorder most probably caused by an abnormal immune reaction to wheat gliadin. The identification of the HLA-DQ2 and HLA-DQ8 as the molecules responsible for the HLA association in coeliac disease strongly implicates a role for CD4 T cells in disease pathogenesis. Indeed, CD4 T cells specific for gliadin have been isolated from the small intestine of...

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PMID: 10601054
DOI: 10.1136/gut.46.1.46

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