Article
Modeling stochastic gene expression: implications for haploinsufficiency.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Cook D L, Gerber A N, Tapscott S J
Abstract excerpt
There is increasing recognition that stochastic processes regulate highly predictable patterns of gene expression in developing organisms, but the implications of stochastic gene expression for understanding haploinsufficiency remain largely unexplored. We have used simulations of stochastic gene...
Topics
- Computer Simulation
- Diploidy
- Gene Expression Regulation
- Haplotypes
- Humans
- Kinetics
- Models, Genetic
- Models, Statistical
- Mutation
- Phenotype
- Software
- Stochastic Processes
- Time Factors