Article
Formation of granular cytoplasmic aggregates in COS7 cells expressing mutant Cu/Zn superoxide dismutase associated with familial amyotrophic lateral sclerosis.
Neuroscience letters - 20 Nov 1998
Koide T, Igarashi S, Kikugawa K, Nakano R, Inuzuka T, Yamada M, Takahashi H, Tsuji S
Abstract excerpt
To investigate the molecular mechanisms of the 'gain of toxic function' of mutant Cu/Zn superoxide dismutase (SOD) associated with familial amyotrophic lateral sclerosis (FALS), mutant (Ala 4 --> Thr, Gly 85 --> Arg, Gly 93 --> Ala, and two base-pair deletion in the 126th codon), as well as wild-...
Topics
- Amino Acid Substitution
- Amyotrophic Lateral Sclerosis
- Animals
- Blotting, Western
- COS Cells
- Cytoplasm
- Cytoplasmic Granules
- Gene Expression
- Mitochondria
- Mutation
- Superoxide Dismutase
- Time Factors
- Transfection