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Article

Aggregate formation in Cu,Zn superoxide dismutase-related proteins.

The Journal of biological chemistry - 18 Apr 2003

Son Marjatta, Cloyd C Dyan, Rothstein Jeffrey D, Rajendran Bhagya, Elliott Jeffrey L

Abstract excerpt

Aggregation of Cu,Zn superoxide dismutase (SOD1) protein is a pathologic hallmark of familial amyotrophic lateral sclerosis linked to mutations in the SOD1 gene, although the structural motifs within mutant SOD1 that are responsible for its aggregation are unknown. Copper chaperone for SOD1 (CCS) and extracellular Cu,Zn superoxide dismutase (SOD3) have some sequence identity with SOD1, particularly in the regions...

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Source

Identifiers

PMID: 12551935
DOI: 10.1074/jbc.M211698200

Genes

SOD1
CCS
SOD3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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