Problems with parsimony in sequences of biased base composition.

doi:10.1007/pl00006427

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Article

Problems with parsimony in sequences of biased base composition.

Journal of molecular evolution - 1 Dec 1998

Eyre-Walker A

Abstract excerpt

Parsimony is commonly used to infer the direction of substitution and mutation. However, it is known that parsimony is biased when the base composition of the DNA sequence is skewed. Here I quantify this effect for several simple cases. The analysis demonstrates that parsimony can be misleading even when levels of sequence divergence are as low as 10%; parsimony incorrectly infers an excess of common to rare...

Topics

Base Composition
Bias
DNA
Evolution, Molecular
Models, Genetic
Mutation

Source

Open in PubMed

Identifiers

PMID: 9847410
DOI: 10.1007/pl00006427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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