Article
Strong suppression of feeding by a peptide containing both the nuclear localization sequence of fibroblast growth factor-1 and a cell membrane-permeable sequence.
Neuroscience letters - 9 Oct 1998
Li A J, Tsuboyama H, Komi A, Ikekita M, Imamura T
Abstract excerpt
Earlier studies have shown that fibroblast growth factor (FGF)-1 in the brain regulates feeding behavior. In the present study, food intake in rats was strongly suppressed by an infusion into the lateral cerebroventricle of a synthetic peptide (26 amino acids) which contains both the N-terminal n...
Topics
- Amino Acid Sequence
- Animals
- Cell Membrane Permeability
- Drinking Behavior
- Feeding Behavior
- Fibroblast Growth Factor 1
- Fibroblast Growth Factor 2
- Injections, Intraventricular
- Male
- Molecular Sequence Data
- Mutation
- Nuclear Localization Signals
- Peptide Fragments
- Rats
- Rats, Wistar