Enhanced impairment of chain elongation by inhibitors of HIV reverse transcriptase in cell-free reactions yielding longer DNA products.

doi:10.1093/nar/26.24.5692

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Article

Enhanced impairment of chain elongation by inhibitors of HIV reverse transcriptase in cell-free reactions yielding longer DNA products.

Nucleic acids research - 15 Dec 1998

Quan Y, Liang C, Inouye P, Wainberg M A

Abstract excerpt

We have studied the relationship between the length of HIV-1 reverse transcriptase (RT)-mediated nucleotide polymerization and inhibitors of these reactions in cell-free RT assays performed in the presence of either of two dideoxynucleoside triphosphates (ddNTPs), i.e. AZTTP or 3TCTP, or nevirapi...

Topics

Cell-Free System
DNA
HIV Reverse Transcriptase
Mutation
Oligonucleotides
Structure-Activity Relationship

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