Article
Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy.
British journal of pharmacology - 1 Oct 1998
Bertrand S, Weiland S, Berkovic S F, Steinlein O K, Bertrand D
Abstract excerpt
1. Physiological and pharmacological properties of the human neuronal alpha4beta2 nicotinic AChR and mutants found in patients suffering from autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) were studied. 2. Investigations of nicotinic AChRs reconstituted in Xenopus oocytes with the co...
Topics
- Animals
- Brain
- Calcium
- Cells, Cultured
- Circadian Rhythm
- DNA Mutational Analysis
- Dose-Response Relationship, Drug
- Epilepsy, Frontal Lobe
- Humans
- Mutation
- Oocytes
- Receptors, Nicotinic
- Time Factors
- Xenopus