Article
Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome.
Proceedings of the Association of American Physicians - 1 Jan 2000
Peek R M, Thompson S A, Donahue J P, Tham K T, Atherton J C, Blaser M J, Miller G G
Abstract excerpt
Most persons infected with Helicobacter pylori strains that produce vacuolating cytotoxin and possess cytotoxin-associated gene A (cagA) genotype nonetheless remain asymptomatic, suggesting that additional genes are important in virulence. We hypothesized that adherence to gastric epithelium provides stimuli that induce expression of some virulence genes. Our aims were to identify expression of H. pylori genes...
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