Article
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1996
Pettaway C A, Pathak S, Greene G, Ramirez E, Wilson M R, Killion J J, Fidler I J
Abstract excerpt
The purpose of this study was to determine whether the implantation of human prostate cancer cells into the prostates of nude mice and their subsequent growth there can be used to select variants with increasing metastatic potential. PC-3M and LNCaP cells were injected into the prostates of athym...
Topics
- Animals
- Bone Neoplasms
- Cell Division
- Culture Media
- Dihydrotestosterone
- Genetic Variation
- Humans
- Karyotyping
- Liver Neoplasms
- Lung Neoplasms
- Lymphatic Metastasis
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Metastasis
- Neoplasm Transplantation
- Orchiectomy