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Article

Formation of a stable RuvA protein double tetramer is required for efficient branch migration in vitro and for replication fork reversal in vivo.

The Journal of biological chemistry - 24 Jun 2011

Bradley Alison S, Baharoglu Zeynep, Niewiarowski Andrew, Michel Bénédicte, Tsaneva Irina R

Abstract excerpt

In bacteria, RuvABC is required for the resolution of Holliday junctions (HJ) made during homologous recombination. The RuvAB complex catalyzes HJ branch migration and replication fork reversal (RFR). During RFR, a stalled fork is reversed to form a HJ adjacent to a DNA double strand end, a reaction that requires RuvAB in certain Escherichia coli replication mutants. The exact structure of active RuvAB complexes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21531731
DOI: 10.1074/jbc.M111.233908
PMCID: PMC3121385

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Formation of a stable RuvA protein double tetramer is required for efficient branch migration in vitro and for replication fork reversal in vivo.PMID 21531731Read ↗

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks.Semantic proximity Read ↗

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RuvABC is required to resolve holliday junctions that accumulate following replication on damaged templates in Escherichia coli.Semantic proximity Read ↗

RuvAB is essential for replication forks reversal in certain replication mutants.Semantic proximity Read ↗

Mycobacterium tuberculosis RuvA induces two distinct types of structural distortions between the homologous and heterologous Holliday junctions.Semantic proximity Read ↗

Structure and mechanism of the RuvB Holliday junction branch migration motor.Semantic proximity Read ↗

The RuvABC resolvasome.Semantic proximity Read ↗

Helicase-defective RuvB(D113E) promotes RuvAB-mediated branch migration in vitro.Semantic proximity Read ↗

The RuvAB branch migration translocase and RecU Holliday junction resolvase are required for double-stranded DNA break repair in Bacillus subtilis.Semantic proximity Read ↗

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning.Semantic proximity Read ↗

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