Article
Selective Expression of Estrogen Receptor α and β Isoforms in Human Pituitary Tumors1
1 Nov 1998
Abstract excerpt
The physiological effects of estrogen on the pituitary, including cellular proliferation and regulation of hormone synthesis, are mediated by the nuclear estrogen receptor (ER). The ER acts as a dimer to modulate gene transcription and contains specific functional domains encoded in different exons. Two separate, but related, forms of the receptor (ERalpha and ERbeta) exist, with distinct tissue and cell patterns...
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