Blood-brain barrier phenylalanine transport and individual vulnerability in phenylketonuria.

doi:10.1097/00004647-199811000-00004

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Article

Blood-brain barrier phenylalanine transport and individual vulnerability in phenylketonuria.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Nov 1998

Möller H E, Weglage J, Wiedermann D, Ullrich K

Abstract excerpt

In vivo nuclear magnetic resonance spectroscopy can be used to measure intracerebral phenylalanine (Phe) concentrations in patients with phenylketonuria (PKU). Stationary levels, obtained under free nutrition, as well as time courses after an oral Phe load (100 mg/kg) were investigated in 11 PKU...

Topics

Adolescent
Adult
Blood-Brain Barrier
Brain
Child
Female
Genotype
Humans
Kinetics
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Phenylalanine
Phenylalanine Hydroxylase
Phenylketonurias
Point Mutation

Source

Open in PubMed

Identifiers

PMID: 9809507
DOI: 10.1097/00004647-199811000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9809507-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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