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Article

Individual blood-brain barrier phenylalanine transport determines clinical outcome in phenylketonuria.

Annals of neurology - 1 Oct 2001

Weglage J, Wiedermann D, Denecke J, Feldmann R, Koch H G, Ullrich K, Harms E, Möller H E

Abstract excerpt

Different clinical outcomes in spite of comparable dietary controls are well known in patients with phenylketonuria. Currently, reasons for this phenomenon are unknown. Kinetic investigations in 15 patients with classic phenylketonuria were performed using in vivo nuclear magnetic resonance spectroscopy before and after an oral phenylalanine load (100 mg/kg body weight). Patients' brain phenylalanine...

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Identifiers

PMID: 11601498
DOI: 10.1002/ana.1226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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