Article
Modelling the phenylalanine blood level response during treatment of phenylketonuria.
Journal of inherited metabolic disease - 1 Dec 2001
Langenbeck U, Zschocke J, Wendel U, Hönig V
Abstract excerpt
A vast body of phenylketonuria (PKU) patient monitoring data is deposited in clinical files and, after having served the actual needs, has remained there largely unused. We propose a kinetic model that will allow continued analysis of such data for further elucidation of the patient's metabolic phenotype and phenylalanine (Phe) disposal characteristics. Our PKU model of a single compartment with the input of...
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