Mutations in BRCA1 from fixed, paraffin-embedded tissue can be artifacts of preservation.

doi:10.1016/s0165-4608(98)00079-x

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Article

Mutations in BRCA1 from fixed, paraffin-embedded tissue can be artifacts of preservation.

Cancer genetics and cytogenetics - 1 Nov 1998

Wong C, DiCioccio R A, Allen H J, Werness B A, Piver M S

Abstract excerpt

DNA isolated from paraffin-embedded tissues has been used for analysis of DNA alterations in disease states. Use of archival tissue can expedite the gathering of large numbers of specimens from rare disease subtypes that would take years to accumulate prospectively. Therefore, archival tissues fr...

Topics

Adult
Artifacts
Carcinoma
DNA Mutational Analysis
DNA, Neoplasm
Female
Genes, BRCA1
Genetic Markers
Humans
Mutation
Ovarian Neoplasms
Paraffin Embedding
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA

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