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Article

Mutations in BRCA1 from fixed, paraffin-embedded tissue can be artifacts of preservation.

Cancer genetics and cytogenetics - 1 Nov 1998

Wong C, DiCioccio R A, Allen H J, Werness B A, Piver M S

Abstract excerpt

DNA isolated from paraffin-embedded tissues has been used for analysis of DNA alterations in disease states. Use of archival tissue can expedite the gathering of large numbers of specimens from rare disease subtypes that would take years to accumulate prospectively. Therefore, archival tissues from 70 ovarian cancer cases diagnosed before or at age 40 were retrieved for analysis of BRCA1 mutations. DNA was...

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Source

Identifiers

PMID: 9809029
DOI: 10.1016/s0165-4608(98)00079-x

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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