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Article

Is a low leptin concentration, a low resting metabolic rate, or both the expression of the "thrifty genotype"? Results from Mexican Pima Indians.

The American journal of clinical nutrition - 1 Nov 1998

Fox C S, Esparza J, Nicolson M, Bennett P H, Schulz L O, Valencia M E, Ravussin E

Abstract excerpt

BACKGROUND: The high prevalence of obesity and type 2 diabetes in some populations is believed to be the expression of a "thrifty genotype," which conferred survival advantages during periods of harsh environmental conditions, but has become a liability in industrialized environments of abundance. Low plasma leptin concentrations and a low metabolic rate may be the phenotypic expression of this genotype....

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Identifiers

PMID: 9808222
DOI: 10.1093/ajcn/68.5.1053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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