Article
Does intracytoplasmic sperm injection lead to a rise in the frequency of microdeletions in the AZFc region of the Y chromosome in future generations?
Human reproduction (Oxford, England) - 1 Oct 1998
Kremer J A, Tuerlings J H, Borm G, Hoefsloot L H, Meuleman E J, Braat D D, Brunner H G, Merkus H M
Abstract excerpt
Microdeletions in the AZFc region of the Y chromosome are found in oligo- and azoospermic men. These mutations were genetically lethal before the intracytoplasmic sperm injection (ICSI) era but they can nowadays be transmitted to next generations via ICSI. We have tried to answer the question, 'D...
Topics
- Chromosome Deletion
- Female
- Fertilization in Vitro
- Gene Frequency
- Humans
- Infant, Newborn
- Male
- Mathematics
- Microinjections
- Models, Genetic
- Mutation
- Oligospermia