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Article

Does intracytoplasmic sperm injection lead to a rise in the frequency of microdeletions in the AZFc region of the Y chromosome in future generations?

Human reproduction (Oxford, England) - 1 Oct 1998

Kremer J A, Tuerlings J H, Borm G, Hoefsloot L H, Meuleman E J, Braat D D, Brunner H G, Merkus H M

Abstract excerpt

Microdeletions in the AZFc region of the Y chromosome are found in oligo- and azoospermic men. These mutations were genetically lethal before the intracytoplasmic sperm injection (ICSI) era but they can nowadays be transmitted to next generations via ICSI. We have tried to answer the question, 'Does ICSI lead to a significant rise in the frequency of these microdeletions in future generations?', by developing a...

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PMID: 9804235
DOI: 10.1093/humrep/13.10.2808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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