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Article

Men with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertility

1 Jul 1999

Abstract excerpt

Deletion of the AZFc region of the Y chromosome is the most frequent molecularly defined cause of spermatogenic failure. We report three unrelated men in whom azoospermia or severe oligozoospermia was caused by de-novo AZFc deletions, and who produced sons by intracytoplasmic sperm injection (ICSI). We employed polymerase chain reaction (PCR) assays to examine the Y chromosomes of their four infant sons. All four...

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Identifiers

PMID: 10402375
DOI: 10.1093/humrep/14.7.1722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Men with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertilityPMID 10402375Read ↗

Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI.Semantic proximity Read ↗

Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number.Semantic proximity Read ↗

The effects of Y chromosome microdeletions on in vitro fertilization outcomes, health abnormalities in offspring and recurrent pregnancy lossSemantic proximity Read ↗

Outcomes of intracytoplasmic sperm injection in oligozoospermic men with Y chromosome AZFb or AZFc microdeletionsSemantic proximity Read ↗

Y-microdeletions: a review of the genetic basis for this common cause of male infertilitySemantic proximity Read ↗

Azoospermia factor C subregion of the Y chromosomeSemantic proximity Read ↗

Defining regions of the Y-chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y-chromosome microdeletion detection.Semantic proximity Read ↗

Y-Chromosome Microdeletions: A Review of Prevalence, Screening, and Clinical ConsiderationsSemantic proximity Read ↗

Y chromosome deletions in azoospermic and severely oligozoospermic men undergoing intracytoplasmic sperm injection after testicular sperm extractionSemantic proximity Read ↗

Decreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosomeSemantic proximity Read ↗

Organizational and functional status of the Y-linked genes and loci in the infertile patients having normal spermiogram.Semantic proximity Read ↗

Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated spermSemantic proximity Read ↗

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