Use of replication deficient adenoviruses to investigate the role of G proteins in Ca2+ signalling in epithelial cells.

doi:10.1016/s0143-4160(98)90077-x

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Article

Use of replication deficient adenoviruses to investigate the role of G proteins in Ca2+ signalling in epithelial cells.

Cell calcium - 1 Aug 1998

Poronnik P, O'Mullane L M, Harding E A, Greger R, Cook D I

Abstract excerpt

Here we report on the feasibility of using replication deficient adenoviruses to modify signal transduction systems in epithelia. We constructed two viruses, one expressing a dominant negative mutant of the alpha-subunit of Gq (Ad-EF1-dnG alpha q) and the other expressing the wild-type alpha-subu...

Topics

Adenoviridae
Calcium Signaling
Carbachol
Carcinoma
Colonic Neoplasms
Epithelial Cells
GTP-Binding Proteins
Genes, Dominant
Green Fluorescent Proteins
Humans
Luminescent Proteins
Muscarinic Agonists
Mutation
Receptors, Muscarinic
Recombinant Proteins
Submandibular Gland
Tumor Cells, Cultured
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 9803310
DOI: 10.1016/s0143-4160(98)90077-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9803310-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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