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Article

MVAC chemotherapy-induced apoptosis and p53 alterations in the rat model of bladder cancer.

Urology - 1 Nov 1998

Zhang X, Jin L, Takenaka I

Abstract excerpt

OBJECTIVES: To investigate the induction of apoptosis by methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) therapy as well as p53 alterations in a rat model of bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). METHODS: At 20 and 28 weeks after starting the administration of BBN, 60 rats (30 at 20 weeks, and 30 at 28 weeks) were divided into an MVAC treatment group (20 rats) and a...

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Identifiers

PMID: 9801132
DOI: 10.1016/s0090-4295(98)00364-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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