MVAC chemotherapy-induced apoptosis and p53 alterations in the rat model of bladder cancer.

doi:10.1016/s0090-4295(98)00364-1

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Article

MVAC chemotherapy-induced apoptosis and p53 alterations in the rat model of bladder cancer.

Urology - 1 Nov 1998

Zhang X, Jin L, Takenaka I

Abstract excerpt

OBJECTIVES: To investigate the induction of apoptosis by methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) therapy as well as p53 alterations in a rat model of bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). METHODS: At 20 and 28 weeks after starting the administ...

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Cisplatin
Doxorubicin
Genes, p53
Male
Methotrexate
Mutation
Rats
Rats, Wistar
Urinary Bladder Neoplasms
Vinblastine

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