Article
Cholesterol synthesis is increased in mixed hyperlipidaemia.
Biochimica et biophysica acta - 2 Nov 1998
Naoumova R P, Kim K D, Neuwirth C, Niththyananthan S, Rendell N B, Taylor G W, Thompson G R
Abstract excerpt
We showed previously that hypertriglyceridaemia, but not hypercholesterolaemia, is correlated with increases in cholesterol synthesis and apolipoprotein B secretion in patients with secondary hypertriglyceridaemia. The aim of the present study was to compare the rate of cholesterol synthesis, using fasting plasma mevalonic acid (MVA) as an index, in patients with primary mixed hyperlipidaemia (type IIb phenotype,...
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