Article
Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia.
Metabolism: clinical and experimental - 1 Mar 1991
Kempen H J, Gevers Leuven J A, van der Voort H A, de Knijff P, Havekes L
Abstract excerpt
We measured the serum lathosterol level, a reflection of the rate of whole body cholesterol synthesis, in 15 patients with manifest type III hyperlipoproteinemia (HLP), in 20 subjects with apolipoprotein (apo) E2/2 phenotype, but without type III HLP, in 21 patients with type IIA and 10 patients with type IIB HLP. A group of 100 subjects with apo E3/3 phenotype served as reference. Using ANCOVA, lathosterol was...
Topics
- Analysis of Variance
- Apolipoprotein E2
- Apolipoproteins E
- Cholesterol
- Humans
- Hyperlipoproteinemia Type II
- Hyperlipoproteinemia Type III
- Isomerism
- Phenotype
- Phytosterols