Article
A Huntington disease-like neurodegenerative disorder maps to chromosome 20p.
American journal of human genetics - 1 Nov 1998
Xiang F, Almqvist E W, Huq M, Lundin A, Hayden M R, Edström L, Anvret M, Zhang Z
Abstract excerpt
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor disturbance, cognitive loss, and psychiatric manifestations. The disease is associated with a CAG trinucleotide-repeat expansion in the Huntington gene (IT15) on chromosome 4p16.3. One family with a history of HD was referred to us initially for predictive testing using linkage analysis. However, the chromosome 4p...
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