Article
Cell interactions with collagen matrices in vivo and in vitro depend on phosphatidylinositol 3-kinase and free cytoplasmic calcium.
Cell adhesion and communication - 1 Sept 1998
Ahlén K, Berg A, Stiger F, Tengholm A, Siegbahn A, Gylfe E, Reed R K, Rubin K
Abstract excerpt
We have investigated the role of phosphatidylinositol 3-kinase (PI3-kinase) in cellular interactions with collagenous matrices. Platelet-derived growth factor-BB (PDGF-BB) elicited a mobilization of intracellular Ca2+ in pig aortic endothelial (PAE) cells transfected with wild type PDGF beta-rece...
Topics
- Androstadienes
- Animals
- Antibodies, Monoclonal
- Becaplermin
- Calcium Signaling
- Cell Communication
- Cells, Cultured
- Chemotaxis
- Chromones
- Collagen
- Endothelium, Vascular
- Extracellular Matrix
- Fibroblasts
- Inositol 1,4,5-Trisphosphate
- Inositol Phosphates
- Integrin beta1
- Morpholines
- Mutation