Article
Mechanism of synergism between antimicrobial peptides magainin 2 and PGLa.
Biochemistry - 27 Oct 1998
Matsuzaki K, Mitani Y, Akada K Y, Murase O, Yoneyama S, Zasloff M, Miyajima K
Abstract excerpt
The antimicrobial peptides magainin 2 and PGLa, discovered in the skin of the African clawed frog, Xenopus laevis, exhibit marked synergism [Westerhoff, H. V., Zasloff, M., Rosner, J. L., Hendler, R. W., de Waal, A., Vaz Gomes, A., Jongsma, A. P. M., Riethorst, A., and Juretic, D., Eur. J. Biochem. 228, 257-264 (1995)], although the mechanism is not yet clear. They are believed to kill bacteria by permeabilizing...
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