Article
Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility.
Cancer research - 15 Oct 1998
Ross R K, Pike M C, Coetzee G A, Reichardt J K, Yu M C, Feigelson H, Stanczyk F Z, Kolonel L N, Henderson B E
Abstract excerpt
The prostate is an androgen-regulated organ, which has led to long-standing interest in the role of androgens in prostate carcinogenesis. Although evidence of a hormonal etiology for prostate cancer is strong, it is almost entirely circumstantial. Much of the problem in proving a causal relations...
Topics
- 3-Hydroxysteroid Dehydrogenases
- Androgens
- Cholestenone 5 alpha-Reductase
- Genetic Predisposition to Disease
- Humans
- Male
- Models, Genetic
- Oxidoreductases
- Prostatic Neoplasms
- Receptors, Androgen
- Steroid 17-alpha-Hydroxylase