Article
Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility.
Cancer research - 15 Oct 1998
Ross R K, Pike M C, Coetzee G A, Reichardt J K, Yu M C, Feigelson H, Stanczyk F Z, Kolonel L N, Henderson B E
Abstract excerpt
The prostate is an androgen-regulated organ, which has led to long-standing interest in the role of androgens in prostate carcinogenesis. Although evidence of a hormonal etiology for prostate cancer is strong, it is almost entirely circumstantial. Much of the problem in proving a causal relationship relates to the continued difficulties in reliably measuring human tissue-specific exposure to endogenous steroid...
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