Article
Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.
Biochemical pharmacology - 15 Oct 1998
Landau M, Weizman A, Zoref-Shani E, Beery E, Wasseman L, Landau O, Gavish M, Brenner S, Nordenberg J
Abstract excerpt
In this study, we evaluated the effect of several ligands active at the central-type and peripheral-type benzodiazepine receptor (BzR) (clonazepam, diazepam, PK11195 and Ro5-4864) on the growth and differentiation of B16 melanoma cells. All tested BzR ligands were able to suppress proliferation o...
Topics
- Animals
- Antineoplastic Agents
- Benzodiazepinones
- Cell Cycle
- Cell Differentiation
- Cell Division
- Clonazepam
- Diazepam
- GABA Agents
- Isoquinolines
- Melanoma, Experimental
- Mice
- Nucleotides
- Phenotype
- Tumor Cells, Cultured
- gamma-Glutamyltransferase