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Article

Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.

Biochemical pharmacology - 15 Oct 1998

Landau M, Weizman A, Zoref-Shani E, Beery E, Wasseman L, Landau O, Gavish M, Brenner S, Nordenberg J

Abstract excerpt

In this study, we evaluated the effect of several ligands active at the central-type and peripheral-type benzodiazepine receptor (BzR) (clonazepam, diazepam, PK11195 and Ro5-4864) on the growth and differentiation of B16 melanoma cells. All tested BzR ligands were able to suppress proliferation of the cells at the micromolar range and in a concentration-dependent manner. However, agents selectively active at the...

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Identifiers

PMID: 9776314
DOI: 10.1016/s0006-2952(98)00149-x

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