Article
Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells.
Molecular and cellular biochemistry - 1 Jul 2010
Mukhopadhyay Sutapa, Guillory Bobby, Mukherjee Shyamali, Das Salil K
Abstract excerpt
This study aims to establish the antiproliferative effects of PK11195, a peripheral benzodiazepine receptor antagonist (PBR) in rat mammary tumor cells. Breast tumors were induced by administration of a carcinogen, dimethylbenz[a]anthracene to 50-day-old female rats maintained on a standard AIN-76A diet with casein as the protein source. The tumors were developed approximately after 120 days. The tumors were of...
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