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Article

Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene

1 Nov 1998

Abstract excerpt

For proper male sexual differentiation, anti-Müllerian hormone (AMH) must be tightly regulated during embryonic development to promote regression of the Müllerian duct. However, the molecular mechanisms specifying the onset of AMH in male mammals are not yet clearly defined. A DNA-binding element for the steroidogenic factor 1 (SF-1), a member of the orphan nuclear receptor family, located in the AMH proximal...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 9774680
DOI: 10.1128/mcb.18.11.6653

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Related research

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Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone GenePMID 9774680Read ↗

Regulation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Sox ProteinsSemantic proximity Read ↗

The nuclear receptor SF-1 mediates sexually dimorphic expression of Müllerian Inhibiting Substance, in vivoSemantic proximity Read ↗

Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-related protein SOX9ASemantic proximity Read ↗

Steroidogenic Factor-1 Regulates Transcription of the Human Anti-müllerian Hormone ReceptorSemantic proximity Read ↗

The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]Semantic proximity Read ↗

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.Semantic proximity Read ↗

In Vivo Ablation of the Conserved GATA-Binding Motif in the Amh Promoter Impairs Amh Expression in the Male MouseSemantic proximity Read ↗

Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination.Semantic proximity Read ↗

A conserved NR5A1-responsive enhancer regulates SRY in testis-determinationSemantic proximity Read ↗

Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRYSemantic proximity Read ↗

Subcellular and Molecular Mechanisms Regulating Anti-Müllerian Hormone Gene Expression in Mammalian and Nonmammalian SpeciesSemantic proximity Read ↗

Androgens downregulate anti-Müllerian hormone promoter activity in the Sertoli cell through the androgen receptor and intact steroidogenic factor 1 sites†Semantic proximity Read ↗

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