Article
Characterization of an ochratoxin-A-dedifferentiated and cloned renal epithelial cell line.
Toxicology and applied pharmacology - 1 Sept 1998
Gekle M, Gassner B, Freudinger R, Mildenberger S, Silbernagl S, Pfaller W, Schramek H
Abstract excerpt
Ochratoxin A (OTA) is a ubiquitous fungal metabolite with predominant nephrotoxic action. OTA impairs postproximal renal electrolyte handling and increases the incidence of renal adenoma and carcinoma. Furthermore, it is supposed to be involved in the pathogenesis of different forms of human rena...
Topics
- Animals
- Biological Transport
- Cell Differentiation
- Cell Division
- Cell Line, Transformed
- Chromosome Aberrations
- Clone Cells
- Dogs
- Epithelial Cells
- Karyotyping
- Kidney Tubules, Collecting
- Mycotoxins
- Ochratoxins
- Phenotype