Article
A novel mechanism for upregulation of the Escherichia coli K-12 hmp (flavohaemoglobin) gene by the 'NO releaser', S-nitrosoglutathione: nitrosation of homocysteine and modulation of MetR binding to the glyA-hmp intergenic region.
Molecular microbiology - 1 Aug 1998
Membrillo-Hernández J, Coopamah M D, Channa A, Hughes M N, Poole R K
Abstract excerpt
The flavohaemoglobin gene, hmp, of Escherichia coli is upregulated by nitric oxide (NO) in a SoxRS-independent manner. We now show that hmp expression is also upregulated by S-nitrosoglutathione (GSNO, widely used as an NO releaser) and sodium nitroprusside (SNP, which is a NO+ donor). Elevated h...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Bacterial Proteins
- Base Sequence
- Binding Sites
- DNA Primers
- DNA, Bacterial
- Dihydropteridine Reductase
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Glutathione